ASTEROID TRIAL ROSUVASTATIN PDF

Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary. The purpose of this study is to see if 40 mg of rosuvastatin taken daily will reduce . statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound- Derived Coronary Atheroma Burden – ASTEROID. Mar 13, Share via: AddThis.

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Effects of AGI and probucol after percutaneous coronary interventions. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: A secondary efficacy variable, change in normalized total trual volume for the entire artery, was also prespecified.

The second prespecified primary efficacy parameter was the nominal change end of treatment minus baseline in total atheroma volume TAV in the mm subsegment of the coronary tdial with the largest plaque volume at baseline the most diseased segment.

Sign in to customize your interests Sign in to your personal account. This very intensive statin regimen was well tolerated. Purpan Rosuvastatln Hospital, Toulouse J. Videotapes containing baseline and follow-up pullbacks were analyzed in the Intravascular Ultrasound Core Laboratory at the Cleveland Clinic Foundation.

Sign in to save your search Sign in to your personal account. In parallel to clinical outcomes trials, imaging studies have examined the effects of antiatherosclerotic therapies on the progression of atherosclerosis.

The ASTEROID trial: coronary plaque regression with high-dose statin therapy.

Sign in to access your subscriptions Sign in to your personal account. Regression was achieved by reducing LDL-C levels to a mean of Only regression, defined as a reduction in IVUS measures of atheroma burden with CIs not including zero, would yield a successful outcome.

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Patients were examined during scheduled clinic visits every 3 months. Comparison of effects on low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with rosuvastatin versus atorvastatin in patients with type IIa or IIb hypercholesterolemia. Study concept and design: Figure 2 shows a representative cross-section at baseline and follow-up for a patient who exhibited marked regression of disease.

The 22 patients who were withdrawn for ischemic events may represent progressors, a potential source of bias in the trial. The paired studies were then randomly resequenced using codes provided by an outside statistician. After 24 months, patients had evaluable serial IVUS examinations. The operator was instructed to select a starting point for interrogation as far distally as could be safely reached.

Multiple muscle biopsies found no evidence of rhabdomyolysis.

The ASTEROID trial: coronary plaque regression with high-dose statin therapy.

A second patient had an elevated creatine kinase level after a seizure but continued taking the study drug, and creatine kinase levels returned to normal during therapy. Thirty-three patients did not have a final IVUS result analyzed, 13 of whom did not undergo a final IVUS examination and 20 of triql had IVUS results that were not analyzable because of artifacts or pullbacks shorter than the prespecified mm minimum length.

Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels: Nissen, MD ; Stephen J. The number of clinical events in this month trial was too small rosuvashatin any meaningful analysis of the relationship between progression rate and morbidity or mortality.

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The study was screened for image quality at a core laboratory at the Cleveland Clinic Foundation, Cleveland, Ohio, and only patients whose IVUS results met prespecified image quality requirements were eligible for inclusion in the study.

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N Engl J Med. The bottom 2 panels illustrate the same cross-sections, but with measurements superimposed. Register for email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts. This procedure was designed to obtain a series of cross-sectional images at sites identical to the original examination. Each pair of baseline and follow-up IVUS assessments tfial analyzed in a blinded fashion.

The protocol specified enrollment of patients at least 18 years of age who required coronary angiography for rosuvasratin clinical indication, which typically consisted of stable or unstable ischemic chest pain syndromes or abnormal functional studies, such as exercise testing. For patients without 10 contiguous evaluable cross-sections, 8 or 9 cross-sections were used and the results were normalized to compensate for the missing cross-sections.

A total of patients had evaluable IVUS examinations at both baseline and after 24 months of treatment Figure 1. No other financial disclosures were reported.

This change represents a median reduction of 6. A year-old man had an elevated creatine kinase level following an episode of lower back pain that occurred after heavy lifting.