BACKGROUND: Flavobacterium meningosepticum is an uncommon pathogen causing nosocomial pneumonia and meningitis in newborns. It is usually. Elizabethkingia meningoseptica is a gram-negative rod-shaped bacterium widely distributed in . Flavobacterium meningosepticum King, (Approved Lists, ); Chryseobacterium meningosepticum (King, ) Vandamme et al., . Flavobacterium meningosepticum is a gram negative, opportunistic organism which has been implicated in a number of outbreaks of sepsis and meningitis in.

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Studies on a group of previously unclassified bacteria associated with meningitis in infants. In this study, we report the crystal flavonacterium of recombinant GA from Flavobacterium meningosepticum.

F meningosepticum is an opportunistic pathogen of low virulence and rarely causes serious infections in adults. Similar to the human structure, the bacterial GA forms an alphabetabetaalpha sandwich. Find similar proteins by: The patient had an apneic episode following which he was transferred to AKUH.

Epidemic meningitis of the newS horn caused by flavobacteria. Crystal structures of Flavobacterium glycosylasparaginase. Serum bilirubin had risen to total of These enzymes are activated from a single chain precursor by intram Because of resistance to most available antimicrobial agents, intravenous and intraventricular erythromycin was administered to one patient.

Journal of Clinical Microbiology. Wet raised colonies with clear margin and characteristic smell after culturing on blood flavoabcterium. The other eight patients suffered nosocomial bacteremia within a mean period of King who isolated Kingella kingae in was studying unclassified bacteria associated with pediatric meningitis at the Centers for Disease Control and Prevention in Atlanta, when she isolated an organism CDC group IIa that she named Flavobacterium meningosepticum Flavobacterium means “the yellow bacillus ” in Latin ; meningosepticum likewise means “associated with meningitis and sepsis “.


Antimicrobial treatment of Flavobacterium meningosepticum infection.

Eighteen flavobacterikm of F meningosepticum were identified from 16 patients. The presence of the heterotetrameric structure in the crystals is significant because dimerization of precursors has been suggested in the human enzyme to be a prerequisite to trigger autoproteolysis. The active site of Flavobacterium glycosylasparaginase is in an open conformation when compared with the human structure.

Elizabethkingia meningoseptica KingKim et al. Special attention was paid to clinical manifestations, underlying diseases, risk factors, treatments, and prognosis. Ventricular CSF was examined Table and found to be abnormal with Grain flagobacterium bacilli seen on gram stain.

Associated Data Supplementary Materials. Although the organism was resistant to rifampicin and ceftazidime on disc diffusion testing, ceftizoxime was not readily available and an interim therapy was initiated flavobacteriim these drugs.


By using this site, you agree to the Terms of Use and Privacy Policy. In other projects Wikispecies. All except one meningoseptucum survived without sequelae. At AKUH the baby was found to be hypotonic with no spontaneous movements. The results confirm the suitability of the bacterial enzyme as a model to study the consequences of mutations in aspartylglycosaminuria patients.


Flavobacteruum sensitivity clearing around disk and colistin resistance may lead to mistaking this organism as gram positive. Therapy of meningitis due to this organism has been a difficult problem, and we suggest possible modes of therapy, based on our experience and a review of the literature. Only recently has it also been found to meningosepticu soft tissue infection and sepsis in the immunocompetent [9] and in a case of a fatal necrotizing fasciitis in a diabetic patient. The charity was founded over 30 years ago after our founder Trustee, Val Jourdan visited the region as a physiotherapist.

Deposition Data Deposited Date: Research articles conducted on animals, will not be considered for processing or publication in the JPMA.

We also describe the structure of a mutant wherein the N-terminal nucleophile Thr is substituted by a cysteine. Glycosylasparaginase GA is a member of a novel family of N-terminal nucleophile hydrolases that catalytically use an N-terminal residue as both a polarizing base and a nucleophile. Systematic and Applied Microbiology. Reducing the use of unnecessary residual devices and invasive procedures may help reduce the incidence of infection.

Please review our privacy policy. KlimekEufronio Maderazoand Richard Quintiliani. Flavobacterium meningosepticum meningitis in a newborn infant.