The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.

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April Learn how and when to remove this template message. Syndromes associated with mediastinal germ cell tumors include Hematologic Neoplasia and Klinefelter’s syndrome.

These tumors are highly sensitive to radiation therapy and to combination chemotherapy. Wikipedia articles that are too technical from April All articles that are too technical Articles needing expert attention from April All articles needing expert attention Infobox medical condition All articles with vague or ambiguous time Vague or ambiguous time from April Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. In these cases, the mediastinal germ cell tumor develops before or concomitantly with but not after acute megakaryoblastic leukemia.

Germ cell tumors[TI] mediastinum.

Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasopharyngeal angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis. Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. Home About Us Advertise Amazon. These results and those of other analyses suggest that the two malignancies derive from a common founding clone of cells i.

Unencapsulated, homogenous fleshy mass with indistinct boundaries and invasion of adjacent structures, hemorrhage or necrosis. Accessed December 31st, Usually males ages 20 – 49 years, similar to gonadal tumors Cancer ; Seminomas grow relatively slowly and can become very large before causing symptoms.


Click here for information on linking to our website or mediastknum our content or images. Most mediastinal malignant tumors are large and cause symptoms by compressing or invading adjacent structures, including the lungs, pleura, mediastinumm, and chest wall. Histologic grading of pure teratomas has prognostic significance in those neoplasms that are diagnosed in adolescents and young mediastinuj immature teratomas in the latter patients pursue an aggressive clinical course.

mediastinal germinoma

Initial treatment with four courses of bleomycin, etoposide, and cisplatin, followed by surgical resection of any residual disease, is considered standard therapy. Am J Surg Pathol. Page views in to date: This article may be too technical for most readers to understand.

Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic gwrminoma Poor prognosis Case reports germimoma year old boy with shortness of breath, chest pain, fever, irritable cough and weight loss Zhongguo Dang Dai Er Ke Za Zhi ; Regardless of the pathologic subtype, the mediastinal germ cell tumors have a predilection for patients in the first three decades of life. Views Read Edit View history.

Also in this section mediastinal synovial sarcoma mediastinal low-grade extraskeletal osteosarcoma mediastinal pericytic tumors mediastinal leiomyosarcoma mediastinal leiomyoma mediastinal mesenchymal tumors mediastinal tumors mediastinal smooth muscle tumors mediastinal lymphomas mediastinal extramedullary hematopoietic tumor.

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Case report and review of the literature”. Click here for patient mediqstinum inquiries. This page was last edited on 2 Augustat Info – Admin Resources in pathology Technical section.

Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis.

Germinoma with yolk sac component. However, discrepancies between the genetic alterations and immunoprofiles of mediastinal and testicular seminomas have been reported, raising the question of whether techniques that are useful in the diagnosis of gonadal seminoma mediiastinum applicable to its mediastinal counterpart.

Fine needle aspiration biopsy can establish diagnosis with high degree of accuracy Am J Clin Pathol ; In several of these cases, the genetic aberrations in the malignant megakaryoblasts were similar to those in the malignant mediastianl germ cells.


Excised tumor with rib. These neoplasms are often associated with the thymus, and in many cases appear to have originated in the thymus; residual thymic tissue is not identifiable in the highly invasive and malignant germ cell tumor.

Semin Respir Crit Care Med. Rare cases of adult onset acute megakaryoblastic leukemia are associated with malignant mediastinal germ cell nediastinum. The majority of neoplasms are mediastinym cystic teratomas that are incidentally discovered on imaging studies of the thorax. Retrieved from ” https: Metastatic germ cell tumor: Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

Pathology by regions G. Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago.

mediastinal germinoma – – Human pathology

It should be remembered that mediastinal lymph nodes are metastatic sites for primary gonadal germ cell tumors, so that a thorough clinical evaluation is necessary to exclude the latter possibility. Sign up for our Email Newsletters. The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to other auxiliary diagnostic utilities medlastinum detecting seminoma.

However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycinetoposide and cisplatin for either three or four day treatment cycles depending on herminoma location of any metastatic disease. Patients with small tumors usually asymptomatic that gerkinoma resectable usually undergo thoracotomy and attempted complete resection followed by chemotherapy.

Pancoast tumor Solitary pulmonary nodule Central lung Peripheral lung Bronchial leiomyoma.