Intoxicación por paraquat: descripción de un caso clínico Paraquat poisoning: a case .. Early Pulomonary Irradiation in Paraquat (Gramoxone) Poisoning. El paraquat es el agente más importante de la familia de los biperidilos. Es directamente cáustico en la naturaleza, su actividad es herbicida mediante la. Política de cookies. Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante.

Author: Faerg Tujinn
Country: Cuba
Language: English (Spanish)
Genre: Travel
Published (Last): 21 October 2004
Pages: 358
PDF File Size: 12.65 Mb
ePub File Size: 17.62 Mb
ISBN: 718-7-40919-327-3
Downloads: 20294
Price: Free* [*Free Regsitration Required]
Uploader: Kazile

Clinical screening of paraquat in plasma samples using capillary electrophoresis with intoxivacion conductivity detection: It is difficult to find out the effect of pulmonary irradiation on the course of the paraquat lung because the precise plasma and urine paraquat concentration were not available between control and irradiation groups.

Effect of acute paraquat poisoning on CYP isoforms activity in rats by cocktail method. Are you a health professional able to prescribe or dispense drugs? Minor contributions include increased cyclisation of creatine to creatinine because of acidosis and competitive or non-competitive inhibition of creatinine secretion. This suggests a model for DA receptor-mediated potentiation of PQ-induced neurotoxicity. Paraquat is considered to be the main pesticide involved in accidental and intentional poisoning, and intoxicaccion responsible for a high rate of morbidity and mortality.

The best survival effect of IST is the combination of methylprednisolone, cyclophosphamide and daily dexamethasone, especially in patients with younger age.

The USA also achieved the highest number of publications involving international collaboration, with 55 publications, followed by the UK, with 18 publications. This method successfully delivers PQ to the fly at concentrations similar to those of the traditional method but with gramozone possibly confounding complications.

The redox cycling of paraquat has two potentially important consequences relevant to the development of toxicity: Ulinastatin can effectively inhibit this stress as well as cell apoptosis, thereby exerting a neuroprotective effect.

There was no difference between the two cell lines in the uptake of. Hallazgos de un estudio de caso. Multiple pathways for uptake of paraquatmethylglyoxal bis guanylhydrazoneand polyamines. The biochemical improvement following melatonin therapy was more evident than the histopathological one. Western blot assay showed that expressions of GRP78 and cleaved-caspase-3 were significantly lower in the ulinastatin group than in the paraquat group. This study aimed to evaluate the data on cases of acute paraquat poisoning and to compare different variables between survivors and non-survivors.


Cells were pretreated with different doses of silymarin for 3h before exposure to paraquat. New alternatives are also presented and reviewed. Cl 10 A- Logistic regression analysis, receiver operator characteristic ROC curve analysis and Kaplan-Meier curve were applied to evaluate the values of urine paraquat PQ concentration, dose of poison, arterial blood lactate and APACHE II score for predicting the prognosis of patients with acute PQ poisoning.

The HRCT findings of paraquat -induced lung injury were irregular shaped areas of consolidation months after ingestion, and irregular-shaped consolidation and ground-glass opacity or focal honeycombing months later.

Bosentan can reduce inflammation factor release. Farmers with longer farming experience, longer pesticide application years, and upland farming reported an increased risk of paraquat use although the trend was not statistically significant. You can change the settings or obtain more information by clicking here. We observed that paraquat -induced oxidative stress in differentiated SHSY-5Y cells as indicated by an increase in the production of cellular reactive oxygen species ROS. In both the short and long-term exposure studies, increased corticosterone and altered hippocampal glucocorticoid receptor GR levels were induced by paraquatbut surprisingly these effects were blunted in the older mice.

The aim of this current study is to explore the protective effect and potential mechanism of silymarin in paraquat -induced macrophage injury. In this cross sectional study, medical records of all paraquat intoxicated patients were reviewed at Taleghani hospital of Urmia, Iran, from toretrospectively. In this article we present the case of a male patient who suffered a self-inflicted poisoning by Paraquat, which was treated according to the Colombian protocols, although with dark results for the patient.

But early pulmonary irradiation within 4 days after paraquat poisoning with aggressive supportive treatment appears to decrease pulmonary toxicity and contribute survival in patients with mouthful ingestion.

Paraquat PQ is toxic herbicide considerable evidence suggests that oxidative stress lor mitochondrial dysfunction contribute to PQ toxicity. The Length of hospital stay was 5. The preparation and physico-chemical characterization of the nanoparticles was followed by evaluation of zeta potential, pH, size and polydispersion. He recovered after seven weeks of intensive therapy.


Intoxicación por paraquat

The aim of this work is to optimize all factors that can influence this determination. Therefore, we designed this nationwide large-scale population-based retrospective cohort study to investigate the outcome of paraquat poisoning with hemoperfusion and the additional effects of IST combined with hemoperfusion. Studies with type II cells isolated from rat lung also demonstrated uptake of intoxicaciln and spermidine, but paraquat was only a weak inhibitor of spermidine uptake in this system.

Although paraquat poisoning is rare in the general population, it may be considered as one of the most toxic poisons frequently used for suicide attempts, and is A total of adult Wister male rats were randomly assigned to three groups: Our findings support the contention that paraquat itself acted as a systemic stressor, with the pesticide increasing plasma corticosterone, as well gramosone altering neurochemical activity in the locus coeruleus, paraventricular nucleus of the hypothalamus, nucleus accumbens, dorsal striatum, and central amygdala.

There was a problem providing the content you requested

According to different period of poisoning, the 6 cases were divided into 3 stages: In all, 79 pregnant women were recruited from three hospitals located in agricultural areas in Thailand. Moreover, sucralfate was significantly more effective than the control normal saline group and the SB treatment group.

De resultaten van de literatuurstudie worden samengevat gramoxome een overzicht van de bepalingsmetboden van paraquat en diquat in groenten en fruit e. Because of its high toxicity, the European Union withdrew it from its market in On HRCT, pulmonary hemorrhage and edema appeared as diffuse air-space consolidation and pulmonary fibrosis as linear or band-like opacities.

It is vital that health workers know the characteristics of poisoning and its treatment.

Methods Thirty-seven patients with acute paraquat poisoning from June to June were enrolled.